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LGD-4033 boasts high selectivity when it bonds to androgen-receptive cells in the body, opting for those in muscles and bones, but not for those in the brain and eyes.There are several potential advantages to the LNDL-4033 compound. One, it can block the activation signal of anandamide, or an adenylate cyclase inhibitor (ACI) that acts as a powerful anandamide blocker."LNDL-4033 binds with high affinity to anandamide, and its low affinity for ligand is important because the adenylate cyclase inhibitor ACI blocks a key molecular pathway for anandamide-induced anabolic signaling," said Dr. V.M. Kulkarni, senior author and principal investigator for the research team. "LNDL-4033 blocks the action of anandamide, which can be an important factor in the regulation of anabolic signaling in muscles and bones."LNDL-4033 also blocks the action of the enzyme acetyl-CoA lyase, which can help break down and create the energy molecule lactic acid during muscle contraction, a process that contributes to gains in muscle mass and strength."While it is still in the research phase, our results indicate that this compound appears to be more efficacious than the previous inhibitors as a means of reducing anabolism in body tissues where anandamide levels are elevated," said Kulkarni."In addition, it is thought that anandamide is the dominant carrier for the anabolic signaling molecules that increase muscle mass and strength in humans," said Dr. Peter G. Tordoff, lead author and professor of physiology and biochemistry at the University of Minnesota. "We found that, unlike other noncompetitive ligands to anandamide such as a synthetic adenosine analog (ASA), LNDL-4033 is non-selective in inhibiting anandamide release.""This compound may be used to treat many different metabolic diseases of aging," Tordoff continued. "For example, we are exploring whether lisdexamfetamine dimesylate, or LDX, in combination with LNDL-4033 could be a promising treatment, since LDX can increase androgen signaling in the body without adverse effects on muscle mass and anabolism."This research was supported by the American College of Cardiology Foundation, the National Institutes of Health, the University of Minnesota, the National Institute of Neurological Disorders and Stroke, the National Eye Institute and other research agencies of the National Institutes ofSimilar articles: